In the present study, the sustained release hydrophilic matrix tablets of diclofenac sodium have been formulated using the direct compression technique with almond gum as the natural hydrophilic matrix former. The formulated tablets were evaluated and before the formulation, the almond gum was even evaluated to check out its purity through the parameters like Ash value, flow properties, water absorption test and swelling index. As the method of preparation is direct compression the initial powder blend was evaluated for flow properties. Finally after performing the evaluation of the sustained release hydrophilic matrix tablets of the diclofenac sodium which is having a very less half-life of around 1-2hrs, it was found that the formulation F3 having 45mg of the almond gum had shown optimum drug release after a time period of 24hrs indicating that the required sustained release can be achieved with that concentration of gum in the formulation. In the present scenario the use of the natural gums would help in reducing the severe side effects caused by the synthetic products and the almond gum had proved to be an efficient hydrophilic matrix forming polymer.
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